Fenbendazole is a drug that inhibits the growth of tumor cells by inducing programmed cell death. It also increases the expression of the gene p53, which regulates cellular life cycles. The increased expression of p53 is an important factor in fenbendazole’s anticancer activity.
The drug is currently being tested on human cancer patients. Fenbendazole is also being researched for use in the treatment of kidney and liver disease. There are a number of potential side effects of this drug, which include elevated liver enzymes and stomach discomfort. Adding vitamin E and curcumin may help minimize these side effects. Fenbendazole is also a proven deworming drug. It has also been shown to inhibit the growth of tumors in laboratory animals.
Fenbendazole inhibits the growth of tumor cells by disrupting the microtubules and inhibiting glucose metabolism. Fenbendazole has multiple modes of action, so it may work in combination with other anticancer drugs to fight cancer. Its low toxicity and high safety margin make it a good candidate for treating cancer.
Fenbendazole’s toxicity was also increased when cells were exposed to hypoxia. However, cell numbers in hypoxia-induced cultures were not significantly different from cells in controls and air cultures. In addition, all survival curves were similar: they showed a sharp decline in cell viability at low concentrations, followed by a plateau of constant viability as concentration increased.
The findings from this study showed that fenbendazole inhibits the growth of EMT6 cells. Furthermore, it had an inhibitory effect on clonogenicity and decreased the number of cells in culture. In addition, the drug showed cytostatic and cytotoxic effects on tumor cells.
In mice, fenbendazole inhibited the growth of EMT6 tumors. In addition, fenbendazole did not affect the growth of irradiated tumors. It also slowed tumor growth in a small study. During this study, fenbendazole capsules was given to mice i.d. for three weeks. Afterward, tumors were measured three times a week. In each group, the time to grow four times their volume was calculated.
Fenbendazole belongs to a group of drugs called benzimidazoles. It is a broad- spectrum anthelmintic. It is effective against most types of roundworm species. It is available under several brand names, including Safe-Guard, Panacur, and Mebendazole.